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- Native American societies before European contact
- European exploration in the New World
- The Columbian Exchange
- Labor, slavery, and caste in the Spanish colonial system
- Cultural interactions between Europeans, Native Americans, and Africans
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- How different European colonies developed and expanded
- Transatlantic trade
- Interactions between American Indians and Europeans
- Slavery in the British colonies
- Colonial society and culture
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- The Seven Years’ War
- The American Revolution
- The Articles of Confederation
- The creation and ratification of the Constitution
- Developing an American identity
- Immigration to and migration within America
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- The rise of political parties
- American foreign policy
- Innovations in technology, agriculture, and business
- Debates about federal power
- The Second Great Awakening
- Reform movements
- The experience of African Americans
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- Manifest Destiny
- The Mexican–American War
- Attempts to resolve conflicts over the spread of slavery
- The election of 1860 and Southern secession
- The Civil War
- Reconstruction
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- The settlement of the West
- The "New South"
- The rise of industrial capitalism
- Immigration and migration
- Reform movements
- Debates about the role of government
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- Debates over imperialism
- The Progressive movement
- World War I
- Innovations in communications and technology in the 1920s
- The Great Depression and the New Deal
- World War II
- Postwar diplomacy
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- The Cold War and the Red Scare
- America as a world power
- The Vietnam War
- The Great Society
- The African American civil rights movement
- Youth culture of the 1960s
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- Reagan and conservatism
- The end of the Cold War
- Shifts in the economy
- Migration and immigration
- Challenges of the 21st century
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